Using inhaled argon to improve survival and organ function after cardiac arrest
Inhaled Argon during Cardiopulmonary Resuscitation -A Novel Therapy to Improve Vital Organ Function and Survival after Cardiac Arrest
['FUNDING_OTHER'] · VETERANS HEALTH ADMINISTRATION · NIH-10951491
This study is looking at whether breathing in argon gas during CPR can help protect your organs and improve your chances of surviving a cardiac arrest, making it easier for your heart to start beating again and reducing any brain damage afterward.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | VETERANS HEALTH ADMINISTRATION (nih funded) |
| Locations | 1 site (NASHVILLE, UNITED STATES) |
| Trial ID | NIH-10951491 on ClinicalTrials.gov |
What this research studies
This research investigates the use of inhaled argon gas during cardiopulmonary resuscitation (CPR) to protect vital organs and improve survival rates after cardiac arrest. The study focuses on the protective mechanisms against ischemia/reperfusion injury, which can occur when blood flow is restored after a cardiac event. By administering argon gas immediately upon resuscitation, the research aims to enhance the rate of return of spontaneous circulation and reduce neurological deficits. The approach is based on the unique biological effects of noble gases, which may interact with cellular signaling pathways to provide organ protection.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have suffered a cardiac arrest and are undergoing CPR.
Not a fit: Patients who have not experienced a cardiac arrest or those with conditions that preclude CPR may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could significantly improve survival rates and neurological outcomes for patients who experience cardiac arrest.
How similar studies have performed: While few studies have explored the use of argon in cardiac arrest scenarios, this approach is novel and has not been extensively tested in the context of immediate resuscitation.
Where this research is happening
NASHVILLE, UNITED STATES
- VETERANS HEALTH ADMINISTRATION — NASHVILLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: RIESS, MATTHIAS L. — VETERANS HEALTH ADMINISTRATION
- Study coordinator: RIESS, MATTHIAS L.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.