Using immune therapy to treat cancer spread in the abdomen
TLR Agonist Nano-Immune Therapy for Peritoneal Metastases
This study is looking at a new way to help people with ovarian and colorectal cancers that have spread to the abdomen by using tiny particles to boost the immune system's ability to fight the cancer directly where it is.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of New Mexico Health Scis Ctr NIH-funded |
| Lab location | 1 site (Albuquerque, United States) |
| Project ID | NIH-10979697 on NIH RePORTER |
What this research studies
This research investigates a novel approach to treating peritoneal metastases, which occur when cancer spreads to the abdominal cavity. It focuses on delivering Toll-like receptor (TLR) agonist-modified nanoparticles directly into the peritoneal cavity, aiming to enhance the immune response against ovarian and colorectal cancers. The study will explore how these nanoparticles interact with immune cells and target tumor sites more effectively than traditional methods. By understanding the mechanisms of this delivery method, the research hopes to improve treatment outcomes for patients with these challenging cancers.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with ovarian or colorectal cancer who have peritoneal metastases.
Not a fit: Patients without peritoneal metastases or those with other types of cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide a new, effective treatment option for patients with peritoneal metastases from ovarian and colorectal cancers.
How similar studies have performed: While this approach is innovative, previous studies have shown promise in using localized immune therapies for cancer treatment, suggesting potential for success.
Where this research is happening
Albuquerque, United States
- University of New Mexico Health Scis Ctr — Albuquerque, United States (Active)
Researchers
- Principal investigator: Serda, Rita Elena — University of New Mexico Health Scis Ctr
- Study coordinator: Serda, Rita Elena
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.