Using immune system modulation to improve bone healing with lower doses of BMPs
Evaluating the role of immunomodulation in synergizing BMP-induced bone repair
This study is looking at a new way to help bones heal better by using special proteins and tiny particles that can change how bone cells work, which could mean less medicine is needed and fewer side effects for people with bone injuries.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Arizona State University-Tempe Campus NIH-funded |
| Lab location | 1 site (Tempe, United States) |
| Project ID | NIH-10728000 on NIH RePORTER |
What this research studies
This research investigates how to enhance bone repair by combining bone morphogenetic proteins (BMPs) with immune-modulating microparticles. The goal is to achieve effective bone regeneration at lower BMP doses, reducing potential side effects and costs. The study will utilize innovative hydrogels to deliver BMPs and these microparticles, which release a substance that influences bone cell behavior. By examining the effects of this combination in laboratory and animal models, the research aims to find a more effective treatment for bone healing.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions requiring bone regeneration, such as fractures or bone defects.
Not a fit: Patients with stable bone conditions that do not require surgical intervention or bone healing may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to safer and more effective treatments for patients needing bone repair.
How similar studies have performed: Previous research has shown promise in using immunomodulation to enhance bone healing, suggesting that this approach could be effective.
Where this research is happening
Tempe, United States
- Arizona State University-Tempe Campus — Tempe, United States (Active)
Researchers
- Principal investigator: Holloway, Julianne Leigh — Arizona State University-Tempe Campus
- Study coordinator: Holloway, Julianne Leigh
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.