Using immune-fibroblast interactions to improve skin healing
Leveraging immune-fibroblast interactions for biomaterial induced skin regeneration
This study is looking at how certain immune cells and skin-supporting cells can work together to help heal wounds better, using a special gel that might encourage your skin to regenerate instead of just forming scars, which could lead to nicer healing results for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-10918116 on NIH RePORTER |
What this research studies
This research investigates how interactions between immune cells and fibroblasts can enhance the regeneration of skin elements like hair follicles and adipose tissue in wound healing. The approach involves using a novel biomaterial called Microporous Annealed Particle (MAP) hydrogel, which contains specific immune triggers that may promote better healing responses. By studying these interactions in both mouse models and human wounds, the research aims to shift the healing process from forming scars to regenerating healthy skin. Patients may benefit from improved healing outcomes and reduced scarring.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults with skin wounds that are healing poorly or resulting in significant scarring.
Not a fit: Patients with non-healing wounds due to underlying conditions that are not addressed by this research may not receive benefit.
Why it matters
Potential benefit: If successful, this research could lead to advanced treatments that promote natural skin regeneration and minimize scarring in patients with wounds.
How similar studies have performed: Other research has shown promise in using biomaterials and immune modulation for enhancing wound healing, suggesting this approach may be effective.
Where this research is happening
Los Angeles, United States
- University of California Los Angeles — Los Angeles, United States (Active)
Researchers
- Principal investigator: Scumpia, Philip — University of California Los Angeles
- Study coordinator: Scumpia, Philip
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.