Using immune cells to improve stroke treatment
Targeting monocyte derived macrophage for stroke treatment
['FUNDING_OTHER'] · VETERANS HEALTH ADMINISTRATION · NIH-10922891
This study is looking at how certain immune cells in the body can help people recover after a stroke, focusing on how age and sex might change their response, with the hope of finding new ways to reduce inflammation and support healing in the brain.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | VETERANS HEALTH ADMINISTRATION (nih funded) |
| Locations | 1 site (PITTSBURGH, UNITED STATES) |
| Trial ID | NIH-10922891 on ClinicalTrials.gov |
What this research studies
This research investigates how immune cells, specifically monocyte-derived macrophages, influence recovery after a stroke. By examining the differences in immune responses based on sex and age, the study aims to identify new targets for therapies that could reduce inflammation and promote brain repair. The researchers utilize advanced techniques like single-cell RNA sequencing to analyze brain cells from animal models and correlate findings with patient outcomes. The ultimate goal is to develop clinical treatments that harness the immune system's potential to aid stroke recovery.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have experienced a stroke, particularly those with varying ages and sexes.
Not a fit: Patients who have not suffered a stroke or have chronic neurological conditions unrelated to acute brain injury may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that improve recovery and outcomes for stroke patients.
How similar studies have performed: Previous research has shown promise in targeting immune responses for stroke treatment, but this approach focusing on sex and age distinctions in macrophage responses is relatively novel.
Where this research is happening
PITTSBURGH, UNITED STATES
- VETERANS HEALTH ADMINISTRATION — PITTSBURGH, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HU, XIAOMING — VETERANS HEALTH ADMINISTRATION
- Study coordinator: HU, XIAOMING
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired brain injury