Using immune cells to improve stroke treatment
Official title: Targeting monocyte derived macrophage for stroke treatment
Funded at Veterans Health Administration · NIH-10922891 · Data updated 2026-11-12
This study is looking at how certain immune cells in the body can help people recover after a stroke, focusing on how age and sex might change their response, with the hope of finding new ways to reduce inflammation and support healing in the brain.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Veterans Health Administration NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project start | October 1, 2024 |
| Project end | September 30, 2028 |
| Funding year | 2025 |
| NIH project number | 1I01BX006534-01 |
| Project ID | NIH-10922891 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have experienced a stroke, particularly those with varying ages and sexes.
✕Less likely to help
Patients who have not suffered a stroke or have chronic neurological conditions unrelated to acute brain injury may not benefit from this research.
What this research studies
This research investigates how immune cells, specifically monocyte-derived macrophages, influence recovery after a stroke. By examining the differences in immune responses based on sex and age, the study aims to identify new targets for therapies that could reduce inflammation and promote brain repair. The researchers utilize advanced techniques like single-cell RNA sequencing to analyze brain cells from animal models and correlate findings with patient outcomes. The ultimate goal is to develop clinical treatments that harness the immune system's potential to aid stroke recovery.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that improve recovery and outcomes for stroke patients.
How similar studies have gone: Previous research has shown promise in targeting immune responses for stroke treatment, but this approach focusing on sex and age distinctions in macrophage responses is relatively novel.
Where this research is happening
-
Veterans Health Administration
Pittsburgh, United States Active
Researchers
- Principal investigator: Hu, Xiaoming — Veterans Health Administration
- Study coordinator: Hu, Xiaoming
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.