Using immune cells to combat lung disease from ozone exposure
Harnessing Inflammatory Macrophages to Thwart Lung Disease Caused by Chronic Ozone Exposure
This study is looking at how certain immune cells in your lungs can be changed to help heal damage caused by long-term ozone exposure, which is important for people with asthma and COPD, and it aims to find ways to make these cells better at reducing inflammation and improving lung health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rutgers Biomedical and Health Sciences NIH-funded |
| Lab location | 1 site (Newark, UNITED STATES) |
| Project ID | NIH-10983744 on NIH RePORTER |
What this research studies
This research investigates how certain immune cells, called macrophages, respond to lung injury caused by chronic ozone exposure. It focuses on understanding how these cells can be reprogrammed from a pro-inflammatory state to a healing state, which is crucial for resolving inflammation in conditions like asthma and COPD. The researchers aim to identify mechanisms that hinder this reprogramming and explore the role of a specific receptor involved in this process. By promoting the resolution of inflammation rather than just suppressing it, the study seeks to improve lung health in affected individuals.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with asthma or COPD, particularly those exposed to chronic ozone pollution.
Not a fit: Patients with lung diseases not related to inflammation or ozone exposure may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance the healing process in patients suffering from lung diseases caused by air pollution.
How similar studies have performed: Previous research has shown promise in using macrophage reprogramming to address inflammation, indicating potential for success in this approach.
Where this research is happening
Newark, UNITED STATES
- Rutgers Biomedical and Health Sciences — Newark, United States (Active)
Researchers
- Principal investigator: Laskin, Debra L — Rutgers Biomedical and Health Sciences
- Study coordinator: Laskin, Debra L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.