Using imaging to assess lung infections in premature infants
Official title: Imaging biomarkers of severe respiratory infections in premature infants Phase II
Funded at Kitware, INC. · NIH-10491039 · Data updated 2026-11-12
This study is working on a new, safe way to use X-ray images to help doctors understand how serious respiratory infections are in premature babies, so they can start treatment sooner and improve their health.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Kitware, INC. NIH-funded |
| Lab location | 1 site (Clifton Park, United States) |
| Project start | May 1, 2018 |
| Project end | July 31, 2025 |
| Funding year | 2022 |
| Award (this year) | $826,115 |
| NIH project number | 5R42HL145669-03 |
| Project ID | NIH-10491039 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are premature infants who are at risk of developing severe respiratory infections.
✕Less likely to help
Patients who are not premature or do not have respiratory issues may not benefit from this research.
What this research studies
This research aims to develop a non-invasive imaging tool to predict and evaluate the severity of respiratory infections in premature infants. By utilizing low-radiation X-ray imaging biomarkers, the study seeks to create an objective framework that allows for early interventions in this vulnerable population. The approach involves advanced machine learning techniques to analyze chest X-ray images and identify specific lung disease signatures. This could significantly enhance clinical decision-making and improve outcomes for premature infants suffering from respiratory issues.
Why it matters
Potential benefit: If successful, this research could lead to better prediction and management of respiratory infections in premature infants, potentially reducing morbidity and mortality rates.
How similar studies have gone: Previous research has shown promise in using imaging biomarkers for assessing lung conditions, indicating that this approach may be effective.
Where this research is happening
-
Kitware, INC.
Clifton Park, United States Active
Researchers
- Principal investigator: Linguraru, Marius George — Kitware, INC.
- Study coordinator: Linguraru, Marius George
Related research
Other NIH-funded projects on the same topics.
-
How life circumstances affect brain aging in people with end-stage kidney disease
This project looks at how neighborhood, income, education, and personal resilience relate to earlier memory and thinking problems in adults with end-stage kidney disease.
-
Mitigating HIV-Associated Premature Aging with Cannabinoids
A doctor-scientist team is testing whether cannabis-based anti-inflammatory effects can slow aging-related brain changes in people living with HIV.
-
Megaplasmids and gut microbes in babies and adults
Scientists are studying unusually large plasmids found in the gut bacteria of babies and adults to understand how these big DNA pieces might affect health and antibiotic resistance.
-
Metabolite-based approach to strengthen the premature gut
A doctor-scientist team will test a metabolite and a synthetic version to help the immature intestines of very premature babies develop better defenses against NEC.
-
Center to speed up proven health improvements for people with serious mental illness
A Johns Hopkins-led center aims to bring already-proven heart-health interventions to adults with serious mental illness to cut their early deaths from heart disease.
-
Antenatal steroids to boost lung health in premature babies in Bangladesh
This project tests whether giving steroids before birth helps the lungs grow better in babies born very early in Bangladesh.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.