NIH-funded research NIH-funded research

Using imaging data to predict outcomes in ovarian cancer patients

Official title: Radiomic biomarkers for clinical decision support that predict patient outcomes in serous ovarian carcinoma

Funded at H. Lee Moffitt Cancer Ctr & Res Inst · NIH-11172693 · Data updated 2026-11-12

This study is looking at how regular CT scans can be used to find important clues that help predict how well women with a specific type of ovarian cancer might do after treatment, so doctors can make better choices for their care.

Quick facts

Grant typeNIH-funded research
Study typeNIH-funded research
Funding institutionH. Lee Moffitt Cancer Ctr & Res Inst
NIH-funded
Lab location1 site (Tampa, United States)
Project startSeptember 13, 2024
Project endAugust 31, 2025
Funding year2024
Award (this year)$299,995
NIH project number1R56CA279060-01A1
Project IDNIH-11172693 on NIH RePORTER

Who could benefit from this research

Could help

Ideal candidates for this research are women diagnosed with high-grade serous ovarian carcinoma who are undergoing or have undergone first-line chemotherapy.

Less likely to help

Patients with other types of ovarian cancer or those who are not receiving treatment may not benefit from this research.

What this research studies

This research investigates how computed tomography (CT) images can be transformed into quantitative data to identify biomarkers that predict survival in women with high-grade serous ovarian carcinoma (HGSOC). By analyzing standard CT scans, the study aims to develop non-invasive tools that can help clinicians make better decisions regarding treatment options. The research will focus on a diverse group of patients to ensure the findings are applicable to a wide population. Ultimately, the goal is to improve patient outcomes by identifying those at risk for adverse effects after initial treatment.

Why it matters

Potential benefit: If successful, this research could lead to more personalized treatment plans for ovarian cancer patients, improving survival rates and quality of care.

How similar studies have gone: Previous research has shown promise in using imaging biomarkers for cancer prognosis, suggesting that this approach could be effective.

Where this research is happening

  • H. Lee Moffitt Cancer Ctr & Res Inst
    Tampa, United States
    Active

Researchers

  • Principal investigator: Peres, Lauren Cole — H. Lee Moffitt Cancer Ctr & Res Inst
  • Study coordinator: Peres, Lauren Cole

Related research

Other NIH-funded projects on the same topics.

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  • Blocking CDK7 as a new approach for aggressive ovarian cancer

    This work explores whether blocking a protein called CDK7 can help treat women with high-grade serous ovarian cancer, especially tumors with CDK7 loss or BRCA-related DNA repair problems.

    NIH research University of Pennsylvania · Philadelphia, United States · NIH-11131193

  • New methods to treat a specific type of ovarian cancer

    This study is looking at a tough type of ovarian cancer called high-grade serous tubo-ovarian carcinoma to find out why it often doesn't respond to regular treatments, and it's testing new therapy combinations to help improve outcomes for patients like you.

    NIH research New York University School of Medicine · New York, United States · NIH-11001564

  • A new CAR T cell therapy targeting ovarian cancer

    This study is testing a new type of CAR T cell therapy for women with ovarian cancer that uses special immune cells to better target the cancer and includes a safety feature to help protect patients from side effects.

    NIH research Luminary Therapeutics, INC. · Minneapolis, United States · NIH-10921643

  • Combining trametinib and navitoclax to treat recurrent ovarian cancer

    This study is testing a new combination treatment for women with recurrent ovarian cancer that hasn't responded to standard therapies, aiming to see if it can help improve their outcomes.

    NIH research Dana-Farber Cancer Inst · Boston, United States · NIH-10895326

  • Targeting a specific protein to treat advanced ovarian cancer

    This study is looking at a new way to help people with advanced ovarian cancer by targeting a specific protein that helps cancer cells survive, hoping to make current treatments work better for those who have few options left.

    NIH research University of Pennsylvania · Philadelphia, United States · NIH-10894152

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.