Using imaging and math to map glioblastoma tumors
Mathematical Oncology Systems Analysis Imaging Center (MOSAIC)
['FUNDING_OTHER'] · CEDARS-SINAI MEDICAL CENTER · NIH-11363506
This project combines advanced MRI scans with mathematical models to better understand the cell types and changing makeup of glioblastoma tumors for people with GBM.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CEDARS-SINAI MEDICAL CENTER (nih funded) |
| Locations | 1 site (LOS ANGELES, UNITED STATES) |
| Trial ID | NIH-11363506 on ClinicalTrials.gov |
What this research studies
You would receive detailed MRI imaging linked to small, image-guided tumor biopsies or surgical samples so researchers can match what the scans show with real tissue. The team will run molecular tests such as single-nucleus RNA sequencing to identify which cell types live where inside the tumor. They will build and test mathematical models that use imaging to predict tissue composition and how the tumor may evolve over time. The goal is to make MRI images more informative about the tumor’s biology so care can be more personalized.
Who could benefit from this research
Good fit: People with a diagnosis of glioblastoma who are undergoing MRI and tumor biopsy or surgery and can provide tissue samples would be the ideal candidates.
Not a fit: People without brain tumors, with other cancer types, or who cannot safely undergo MRI or biopsy would not be eligible and are unlikely to benefit from this project.
Why it matters
Potential benefit: If successful, this work could let doctors use routine MRIs to better estimate tumor cell makeup and tailor treatments more precisely for people with glioblastoma.
How similar studies have performed: Previous studies combining imaging and molecular profiling have shown promise, but this integrated, predictive mathematical modeling approach for GBM is relatively new.
Where this research is happening
LOS ANGELES, UNITED STATES
- CEDARS-SINAI MEDICAL CENTER — LOS ANGELES, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SWANSON, KRISTIN R — CEDARS-SINAI MEDICAL CENTER
- Study coordinator: SWANSON, KRISTIN R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.