Using IL-10 to improve immune response and eliminate HIV in treated macaques
Harnessing IL-10 in cART treated SIV infected macaques to restore immunity and to eradicate HIV
['FUNDING_R37'] · EMORY UNIVERSITY · NIH-10849669
This study is looking at how a substance called IL-10 affects HIV in treated macaques, and it aims to see if blocking IL-10 can help boost the immune system to fight off the virus better, which could lead to getting rid of HIV altogether.
Quick facts
| Phase | ['FUNDING_R37'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | EMORY UNIVERSITY (nih funded) |
| Locations | 1 site (ATLANTA, UNITED STATES) |
| Trial ID | NIH-10849669 on ClinicalTrials.gov |
What this research studies
This research investigates the role of Interleukin-10 (IL-10) in maintaining HIV reservoirs in treated macaques. The study aims to neutralize IL-10 to enhance the immune response against HIV, potentially leading to the eradication of the virus. By examining the effects of an anti-IL-10 antibody, researchers hope to restore cellular immunity and reduce the number of latently infected cells. The approach is based on previous findings that suggest IL-10 contributes to the persistence of HIV.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with HIV who are currently receiving combination antiretroviral therapy (cART).
Not a fit: Patients who are not infected with HIV or those who are not on cART may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that effectively eliminate HIV from the body, offering hope for a functional cure.
How similar studies have performed: Previous research has shown promise in targeting IL-10 for HIV treatment, indicating potential for success in this approach.
Where this research is happening
ATLANTA, UNITED STATES
- EMORY UNIVERSITY — ATLANTA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SEKALY, RAFICK PIERRE — EMORY UNIVERSITY
- Study coordinator: SEKALY, RAFICK PIERRE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired Immune Deficiency Syndrome, Acquired Immune Deficiency Syndrome Virus, Acquired Immunodeficiency Syndrome, Acquired Immunodeficiency Syndrome Virus