Using IL-10 to improve immune response and eliminate HIV in treated macaques
Official title: Harnessing IL-10 in cART treated SIV infected macaques to restore immunity and to eradicate HIV
Funded at Emory University · NIH-10849669 · Data updated 2026-11-12
This study is looking at how a substance called IL-10 affects HIV in treated macaques, and it aims to see if blocking IL-10 can help boost the immune system to fight off the virus better, which could lead to getting rid of HIV altogether.
Quick facts
| Grant type | R37 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project start | July 1, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $738,490 |
| NIH project number | 5R37AI141258-08 |
| Project ID | NIH-10849669 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with HIV who are currently receiving combination antiretroviral therapy (cART).
✕Less likely to help
Patients who are not infected with HIV or those who are not on cART may not benefit from this research.
What this research studies
This research investigates the role of Interleukin-10 (IL-10) in maintaining HIV reservoirs in treated macaques. The study aims to neutralize IL-10 to enhance the immune response against HIV, potentially leading to the eradication of the virus. By examining the effects of an anti-IL-10 antibody, researchers hope to restore cellular immunity and reduce the number of latently infected cells. The approach is based on previous findings that suggest IL-10 contributes to the persistence of HIV.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that effectively eliminate HIV from the body, offering hope for a functional cure.
How similar studies have gone: Previous research has shown promise in targeting IL-10 for HIV treatment, indicating potential for success in this approach.
Where this research is happening
-
Emory University
Atlanta, United States Active
Researchers
- Principal investigator: Sekaly, Rafick Pierre — Emory University
- Study coordinator: Sekaly, Rafick Pierre
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.