Using hydroxycitrate to prevent calcium phosphate kidney stones
Official title: Hydroxycitrate: A Novel Therapy for Calcium Phosphate Urinary Stones
Funded at Ut Southwestern Medical Center · NIH-11163455 · Data updated 2026-11-12
This study is looking at whether hydroxycitrate can help people who have had calcium phosphate kidney stones by preventing them from coming back, making it easier for patients to manage their condition without needing more surgeries.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project start | August 5, 2023 |
| Project end | May 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $471,750 |
| NIH project number | 5R01DK136684-03 |
| Project ID | NIH-11163455 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have a history of calcium phosphate kidney stones and experience recurrent stone formation.
✕Less likely to help
Patients who do not have a history of calcium phosphate kidney stones or those with other types of kidney stones may not benefit from this research.
What this research studies
This research investigates the potential of hydroxycitrate as a treatment to prevent the recurrence of calcium phosphate (CaP) kidney stones. Patients with CaP stones often face high rates of stone recurrence and may require multiple surgeries, indicating that current treatments are not effective enough. The study will explore how hydroxycitrate can inhibit the growth of CaP crystals in the body, aiming to improve urine chemistry without raising urine pH, which can worsen stone formation. By analyzing the effects of hydroxycitrate on urine composition, the research seeks to establish a new preventive therapy for those affected by CaP stones.
Why it matters
Potential benefit: If successful, this research could provide a new, effective treatment option for patients suffering from calcium phosphate kidney stones, reducing recurrence rates and the need for surgery.
How similar studies have gone: Preliminary studies have shown promising results for hydroxycitrate in preventing calcium phosphate crystallization, suggesting potential for success in this novel approach.
Where this research is happening
-
Ut Southwestern Medical Center
Dallas, United States Active
Researchers
- Principal investigator: Maalouf, Naim M — Ut Southwestern Medical Center
- Study coordinator: Maalouf, Naim M
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.