Using hydroxychloroquine to improve heart health in patients with chronic kidney disease
Hydroxychloroquine for the Management of CVD in CKD
['FUNDING_OTHER'] · VETERANS HEALTH ADMINISTRATION · NIH-11118654
This study is looking at whether hydroxychloroquine, a safe and affordable medication, can help improve heart health in people with chronic kidney disease and end-stage kidney disease by reducing inflammation and stiffness in blood vessels.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | VETERANS HEALTH ADMINISTRATION (nih funded) |
| Locations | 1 site (GAINESVILLE, UNITED STATES) |
| Trial ID | NIH-11118654 on ClinicalTrials.gov |
What this research studies
This research investigates the potential of hydroxychloroquine, a safe and affordable anti-inflammatory medication, to manage cardiovascular disease (CVD) in patients with chronic kidney disease (CKD) and end-stage kidney disease (ESKD). The study aims to evaluate how hydroxychloroquine can counteract factors like inflammation and vascular stiffness that contribute to CVD in these patients. Previous studies have shown promising results regarding hydroxychloroquine's effects on inflammation and atherosclerosis, and this research will further explore its benefits in a clinical setting. By conducting a proof-of-concept clinical study, the researchers hope to validate the drug's protective effects on cardiovascular health in CKD patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with chronic kidney disease or end-stage kidney disease who are at risk for cardiovascular disease.
Not a fit: Patients with cardiovascular disease who do not have chronic kidney disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to a new treatment option that significantly reduces cardiovascular disease mortality in patients with chronic kidney disease.
How similar studies have performed: Previous studies have shown promising results for hydroxychloroquine in improving cardiovascular health, indicating that this approach has potential based on earlier findings.
Where this research is happening
GAINESVILLE, UNITED STATES
- VETERANS HEALTH ADMINISTRATION — GAINESVILLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SHUKLA, ASHUTOSH M — VETERANS HEALTH ADMINISTRATION
- Study coordinator: SHUKLA, ASHUTOSH M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.