Using hydrogels to improve heart recovery after a heart attack
Official title: Prevention of remodeling by image guided epicardial delivery of hydrogels to the heart
Funded at Yale University · NIH-11168153 · Data updated 2026-11-12
This study is looking at how special gels can be delivered right to the heart after a heart attack to help it heal better and prevent further problems, using gentle methods to see how well the heart is recovering.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | June 1, 2025 |
| Project end | March 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $758,862 |
| NIH project number | 1R01HL175990-01A1 |
| Project ID | NIH-11168153 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have recently experienced a myocardial infarction and are at risk of heart failure.
✕Less likely to help
Patients who have not experienced a heart attack or have advanced heart failure may not benefit from this research.
What this research studies
This research focuses on delivering biomaterials, specifically hydrogels, directly to the heart tissue affected by a heart attack (myocardial infarction) to prevent further damage and improve recovery. By using minimally invasive techniques, the study aims to understand how these hydrogels can stabilize heart function and reduce the risk of heart failure. The approach involves tracking changes in heart mechanics and biological processes using advanced imaging techniques, which could lead to better treatment options for patients recovering from heart attacks.
Why it matters
Potential benefit: If successful, this research could lead to improved recovery outcomes for patients who have suffered a heart attack, potentially reducing the risk of heart failure.
How similar studies have gone: Previous studies have shown promise in using injectable biomaterials for heart recovery, indicating that this approach has potential based on earlier successes.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Sinusas, Albert J — Yale University
- Study coordinator: Sinusas, Albert J
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.