Using human umbilical cord to improve spinal cord repair in babies with spina bifida
Human Umbilical Cord as a Regenerative Meningeal Patch to Prevent Tethering and Improve Neurological Function Following In-Utero Spina Bifida Repair
This study is exploring a new way to help babies with spina bifida by using a special patch made from frozen human umbilical cord during surgery before birth, which could lead to better movement and fewer problems later on.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Sci Ctr Houston NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-11042726 on NIH RePORTER |
What this research studies
This research investigates a novel approach to enhance the outcomes of in-utero spina bifida repair by using a cryopreserved human umbilical cord as a regenerative patch. The study aims to improve long-term spinal cord function and reduce complications such as tethered spinal cord by utilizing the umbilical cord's anti-inflammatory properties. The research is conducted in a sheep model to assess the effectiveness of this method before potential application in human patients. If successful, this approach could lead to better neurological and developmental outcomes for affected children.
Who could benefit from this research
Good fit: Ideal candidates for this research are unborn babies diagnosed with spina bifida who are undergoing in-utero repair.
Not a fit: Patients who have already undergone spina bifida repair or those with other unrelated neurological conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could significantly improve mobility and quality of life for children born with spina bifida.
How similar studies have performed: Previous studies have shown promising results using similar regenerative approaches, indicating potential for success in this novel application.
Where this research is happening
Houston, United States
- University of Texas Hlth Sci Ctr Houston — Houston, United States (Active)
Researchers
- Principal investigator: Papanna, Ramesha — University of Texas Hlth Sci Ctr Houston
- Study coordinator: Papanna, Ramesha
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.