Using human Schwann cell-derived exosomes to treat traumatic brain injury
Official title: Human Schwann Cell-Derived Exosome Treatment for Traumatic Brain Injury
Funded at University of Miami School of Medicine · NIH-10890128 · Data updated 2026-11-12
This study is looking at whether tiny particles called exosomes from human nerve cells can help people recover from traumatic brain injuries by reducing inflammation and improving brain health, and it’s for anyone who has experienced a TBI.
Quick facts
| Grant type | R37 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Miami School of Medicine NIH-funded |
| Lab location | 1 site (Coral Gables, United States) |
| Project start | August 1, 2023 |
| Project end | July 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $409,874 |
| NIH project number | 5R37NS133195-02 |
| Project ID | NIH-10890128 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have experienced a traumatic brain injury and are seeking new treatment options.
✕Less likely to help
Patients with chronic or long-standing brain injuries that are not recent may not benefit from this research.
What this research studies
This research investigates the use of exosomes derived from human Schwann cells as a potential treatment for traumatic brain injury (TBI). The approach involves isolating and administering these exosomes intravenously to target various cellular and molecular mechanisms that contribute to brain injury and repair. The study aims to evaluate the optimal dosage and timing for treatment, assessing its effects on brain structure, biochemistry, and long-term behavioral outcomes. By focusing on anti-inflammatory properties, the research seeks to enhance recovery and improve the quality of life for individuals affected by TBI.
Why it matters
Potential benefit: If successful, this research could lead to a novel therapeutic option that significantly improves recovery outcomes for patients with traumatic brain injury.
How similar studies have gone: Other research has shown promise in using cell-derived exosomes for neurodegenerative conditions, suggesting potential success for this novel approach.
Where this research is happening
-
University of Miami School of Medicine
Coral Gables, United States Active
Researchers
- Principal investigator: Dietrich, W Dalton — University of Miami School of Medicine
- Study coordinator: Dietrich, W Dalton
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.