Using human dopamine cells to treat Parkinson's disease
Human Dopamine Grafts in Alpha-Synuclein Models of Parkinson Disease
This study is exploring whether using special brain cells made from human embryonic stem cells can help improve brain function in people with Parkinson's disease by replacing lost cells and reducing inflammation.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sloan-Kettering Inst Can Research NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10872173 on NIH RePORTER |
What this research studies
This research investigates the potential of using human embryonic stem cell-derived dopamine neurons to restore lost brain function in patients with Parkinson's disease. The approach involves grafting these neurons into the brain to counteract the effects of neuroinflammation and neuronal loss associated with the disease. By studying the brain's microenvironment, the research aims to enhance the survival and integration of these grafted cells, ultimately improving patient outcomes. The research builds on previous clinical trials and seeks to address the challenges faced in neuronal regeneration.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Parkinson's disease who are experiencing significant motor and cognitive symptoms.
Not a fit: Patients with early-stage Parkinson's disease or those who do not have significant neuronal loss may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic options that regenerate lost neurons and restore brain function in Parkinson's disease patients.
How similar studies have performed: Previous clinical trials using stem cell-derived neurons have shown promise, indicating that this approach may lead to significant advancements in treating Parkinson's disease.
Where this research is happening
New York, United States
- Sloan-Kettering Inst Can Research — New York, United States (Active)
Researchers
- Principal investigator: Tabar, Viviane — Sloan-Kettering Inst Can Research
- Study coordinator: Tabar, Viviane
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.