Using HIV-positive organs for liver transplants in HIV-positive patients
HOPE in Action: A Clinical Trial of HIV-to-HIV Liver Transplantation
This study is looking at whether liver transplants from HIV-positive donors can be safe and helpful for people with HIV who need a new liver, aiming to make more organs available and improve the chances of successful transplants for those waiting.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-10459319 on NIH RePORTER |
What this research studies
This research investigates the safety and effectiveness of liver transplantation using organs from HIV-positive donors for HIV-positive recipients. It aims to address the severe organ shortage and high waitlist mortality rates faced by HIV-positive individuals needing liver transplants. By expanding the donor pool to include HIV-positive deceased donors, the study seeks to improve patient outcomes and reduce waiting times. The research will involve a multicenter clinical trial to gather data on the risks and benefits of this approach.
Who could benefit from this research
Good fit: Ideal candidates for this research are HIV-positive individuals suffering from end-stage liver disease who are in need of a liver transplant.
Not a fit: Patients who are not HIV-positive or those who do not require a liver transplant will not benefit from this research.
Why it matters
Potential benefit: If successful, this research could significantly reduce wait times for liver transplants and improve survival rates for HIV-positive patients.
How similar studies have performed: While there have been limited cases of HIV-positive liver transplants, this approach is largely novel and untested on a larger scale.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Durand, Christine Marie — Johns Hopkins University
- Study coordinator: Durand, Christine Marie
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.