Using Hispanic/Latino genetic diversity to find genes linked to heart disease and stroke
Leveraging Hispanic/Latino diversity to map and characterize cardiovascular disease loci
This project looks at DNA from Hispanic/Latino people to find genetic differences that influence risk for heart disease, stroke, diabetes, and high blood pressure.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of North Carolina Chapel Hill NIH-funded |
| Lab location | 1 site (Chapel Hill, United States) |
| Project ID | NIH-11262221 on NIH RePORTER |
What this research studies
If you join, researchers will analyze genetic data and health information from Hispanic/Latino adults to pinpoint DNA variants tied to coronary heart disease, stroke, and related risk factors. They will use large-scale genome scans that take advantage of the mixed ancestry common in Hispanic/Latino populations to improve detection of risk loci. Follow-up analyses will try to identify the likely causal variants and the biological pathways they affect. The goal is to build knowledge that could help tailor prevention, risk prediction, and future treatments for Hispanic/Latino communities.
Who could benefit from this research
Good fit: Adults who identify as Hispanic or Latino (with or without cardiovascular disease) who can provide a DNA sample and health information would be the ideal participants.
Not a fit: People who are not Hispanic/Latino or those expecting immediate medical treatment changes should not expect direct clinical benefits from this genetic mapping work.
Why it matters
Potential benefit: Findings could improve genetic risk prediction and help guide prevention or targeted therapies for Hispanic/Latino patients with cardiovascular conditions.
How similar studies have performed: Large genetic studies in European-ancestry populations have found many heart disease risk loci, but genome-wide studies specifically in Hispanic/Latino groups are scarce, making this approach partly novel for this population.
Where this research is happening
Chapel Hill, United States
- Univ of North Carolina Chapel Hill — Chapel Hill, United States (Active)
Researchers
- Principal investigator: Graff, Mariaelisa — Univ of North Carolina Chapel Hill
- Study coordinator: Graff, Mariaelisa
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.