Using HIF-1alpha mRNA to improve healing of surgical flaps.
Official title: Use of HIF-1alpha mRNA to Promote Pedicle Flap Healing.
Funded at Advanced Molecular Healix INC. · NIH-11064991 · Data updated 2026-11-12
This study is looking at a new way to help heal surgical wounds by using a special treatment that involves injecting a molecule called HIF-1alpha into the skin, which could make the healing process faster and more effective for patients needing reconstructive surgery.
Quick facts
| Grant type | Sbir 1 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Advanced Molecular Healix INC. NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | June 1, 2025 |
| Project end | May 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $296,256 |
| NIH project number | 1R43AR084352-01A1 |
| Project ID | NIH-11064991 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients requiring surgical reconstruction after major wounds, particularly those involving pedicle flaps.
✕Less likely to help
Patients with minor wounds or those not requiring surgical reconstruction may not benefit from this research.
What this research studies
This research investigates the use of HIF-1alpha mRNA to enhance the healing process of pedicle flaps, which are crucial for surgical reconstructions after major wounds. The approach involves injecting HIF-1alpha mRNA into the skin to promote cell survival and revascularization, thereby improving the success of the flap. The study will utilize animal models, specifically Sprague Dawley rats, to assess the effectiveness of this treatment. By leveraging advanced RNA delivery techniques similar to those used in COVID vaccines, the research aims to develop a novel therapeutic strategy for better wound healing.
Why it matters
Potential benefit: If successful, this research could significantly improve healing outcomes for patients undergoing surgical flap procedures.
How similar studies have gone: Other research has shown promise in using mRNA technology for therapeutic applications, indicating potential success for this novel approach.
Where this research is happening
-
Advanced Molecular Healix INC.
Baltimore, United States Active
Researchers
- Principal investigator: Abraham, John M — Advanced Molecular Healix INC.
- Study coordinator: Abraham, John M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.