Using heat to activate CAR T cells for cancer treatment
Image-guided cancer therapy using heat activatable CAR T cells
This study is exploring a new way to make CAR T cell therapy work better for breast cancer by using tiny gold particles and special imaging techniques to help the immune cells target and fight the tumors more effectively, which could lead to a safer and more successful treatment for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Georgia Institute of Technology NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project ID | NIH-10888214 on NIH RePORTER |
What this research studies
This research investigates a novel approach to enhance CAR T cell therapy for solid tumors, particularly breast cancer. It focuses on improving the ability of CAR T cells to infiltrate tumors and overcome the immunosuppressive environment by tagging them with gold nanorods and using thermal gene switches. The therapy is guided by a combination of ultrasound and photoacoustic imaging to ensure precise targeting and activation of the immune response. Patients may benefit from a more effective and safer cancer treatment option.
Who could benefit from this research
Good fit: Ideal candidates for this research would be patients diagnosed with solid tumors, particularly breast cancer, who have not responded to conventional therapies.
Not a fit: Patients with hematological malignancies or those who do not have solid tumors may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective and safer treatments for patients with solid tumors like breast cancer.
How similar studies have performed: While CAR T cell therapy has shown success in hematological cancers, this approach for solid tumors is novel and has not been extensively tested.
Where this research is happening
Atlanta, United States
- Georgia Institute of Technology — Atlanta, United States (Active)
Researchers
- Principal investigator: Emelianov, Stanislav Y — Georgia Institute of Technology
- Study coordinator: Emelianov, Stanislav Y
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.