Using heat and specific agents to treat liver cancer from colorectal metastases
Official title: Assessment of hyperthermia-based multimodal approach for hepatic colorectal metastases
Funded at Cedars-Sinai Medical Center · NIH-10931320 · Data updated 2026-11-12
This study is looking at a new way to treat liver tumors that have come from colorectal cancer by using a combination of heat and special medicines to help kill the cancer cells, and if it works well, it could offer a better option for patients like you.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cedars-Sinai Medical Center NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project start | September 19, 2023 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $413,158 |
| NIH project number | 5R01CA265827-02 |
| Project ID | NIH-10931320 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with unresectable hepatic colorectal metastases who have limited treatment options.
✕Less likely to help
Patients with resectable liver tumors or those with other types of cancer may not benefit from this research.
What this research studies
This research investigates a new treatment approach for patients with unresectable hepatic colorectal metastases, which are liver tumors that have spread from colorectal cancer. The team will explore the combined effects of mild hyperthermia, a biologic agent called TRAIL, and a ferroptotic agent known as artesunate to enhance tumor cell death. By studying how these treatments work together in laboratory models, the researchers aim to develop a more effective therapy that minimizes side effects while targeting the cancer directly. Patients may benefit from this innovative approach if it proves successful in clinical settings.
Why it matters
Potential benefit: If successful, this research could lead to a more effective treatment option for patients with liver metastases from colorectal cancer, potentially improving survival rates.
How similar studies have gone: Previous studies have shown promising results with similar multimodal approaches in cancer treatment, suggesting potential for success in this novel application.
Where this research is happening
-
Cedars-Sinai Medical Center
Los Angeles, United States Active
Researchers
- Principal investigator: Lee, Yong J — Cedars-Sinai Medical Center
- Study coordinator: Lee, Yong J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.