Using heart-rate responses during arm-movement tests to detect irreversible frailty in older adults with severe heart disease
Heart Rate Dynamics in Response to Upper-Extremity Function Test to Identify Irreversible Frailty After Invasive Therapy in Older Adults with Advanced Heart Disease
['FUNDING_R01'] · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · NIH-11260125
This project uses heart-rate changes during a quick arm-movement test to find older adults with severe heart disease who may not tolerate invasive treatments like valve replacement.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | RUTGERS BIOMEDICAL AND HEALTH SCIENCES (nih funded) |
| Locations | 1 site (Newark, UNITED STATES) |
| Trial ID | NIH-11260125 on ClinicalTrials.gov |
What this research studies
You would perform a short, simple upper-arm function test while we record your heart rate with wearable sensors and motion monitors. The team combines how your arm moves and how your heart responds to create a quick, objective frailty score tailored to people with heart disease who face invasive procedures. The focus is on older adults with aortic stenosis being considered for transcatheter aortic valve replacement (TAVR) to reduce variability and make results more relevant. Testing is designed to be brief and usable during routine cardiology visits.
Who could benefit from this research
Good fit: Ideal candidates are adults age 65 and older with advanced heart disease, especially aortic stenosis, who are being considered for invasive therapies such as TAVR.
Not a fit: People under 65, those without advanced heart disease, or those not being considered for invasive cardiac procedures are unlikely to benefit from this specific testing approach.
Why it matters
Potential benefit: If successful, this could help doctors decide who will benefit from invasive heart procedures and who might be better served by less aggressive or preparatory care.
How similar studies have performed: Related sensor-based frailty work has shown promise, but applying heart-rate dynamics during arm tests specifically for heart-disease patients and TAVR selection is a novel approach.
Where this research is happening
Newark, UNITED STATES
- RUTGERS BIOMEDICAL AND HEALTH SCIENCES — Newark, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: TOOSIZADEH, NIMA — RUTGERS BIOMEDICAL AND HEALTH SCIENCES
- Study coordinator: TOOSIZADEH, NIMA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.