Using gut bacteria to treat genetic metabolic disorders
Microbiota-based probiotics to treat inborn errors in metabolism
This study is exploring how helpful bacteria in our gut can be used to treat conditions like Phenylketonuria, with the hope of creating probiotics that can support better metabolism for those affected.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project ID | NIH-11010364 on NIH RePORTER |
What this research studies
This research investigates how gut microbiota can be harnessed to treat inborn errors of metabolism, such as Phenylketonuria. By identifying specific beneficial bacteria and their metabolic pathways, the project aims to develop probiotics that can help manage biochemical defects in patients. The approach involves advanced techniques like gene analysis and metabolomics to understand how these microbes can influence metabolism. Ultimately, the goal is to create a new therapeutic strategy that utilizes the natural capabilities of gut bacteria.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with inborn errors of metabolism, particularly those with Phenylketonuria.
Not a fit: Patients without metabolic disorders or those who do not have a genetic basis for their condition may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide a novel treatment option for patients with genetic metabolic disorders, potentially improving their health and quality of life.
How similar studies have performed: While the use of gut microbiota in metabolic treatment is a relatively novel approach, preliminary studies have shown promise in similar areas, indicating potential for success.
Where this research is happening
Stanford, United States
- Stanford University — Stanford, United States (Active)
Researchers
- Principal investigator: Dodd, Dylan — Stanford University
- Study coordinator: Dodd, Dylan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.