Using Group O whole blood for emergency trauma transfusions
2/2 Trauma Resuscitation with Group O Whole Blood or Products (TROOP)
['FUNDING_OTHER'] · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · NIH-11146466
This trial compares giving Group O whole blood versus the usual separated blood parts to people with severe traumatic injuries who are expected to need large-volume transfusions.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON (nih funded) |
| Locations | 1 site (HOUSTON, UNITED STATES) |
| Trial ID | NIH-11146466 on ClinicalTrials.gov |
What this research studies
If you're brought to the ER with severe injuries and likely need lots of blood, doctors at participating hospitals may randomly give either Group O whole blood or the standard mix of blood components. The trial is a pragmatic, multicenter, phase III randomized comparison focused on early outcomes, especially death at 6 hours, and on monitoring safety and complications. Treatment happens during emergency resuscitation using hospital workflows, and patients are followed closely for adverse events and short-term outcomes. The goal is to test whole blood in real-world trauma care across multiple centers.
Who could benefit from this research
Good fit: Adults with traumatic injuries who clinicians predict will require large-volume blood transfusions at participating trauma centers are the intended participants.
Not a fit: People with minor injuries who do not need transfusion, patients treated outside participating centers, or those excluded for medical reasons are unlikely to benefit directly.
Why it matters
Potential benefit: If successful, this approach could reduce early deaths and simplify emergency transfusions for severely injured patients.
How similar studies have performed: A small number of observational studies have suggested benefits from whole blood, but randomized evidence is limited so this phase III trial addresses a relatively untested approach.
Where this research is happening
HOUSTON, UNITED STATES
- UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON — HOUSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LEON-NOVELO, LUIS GONZALO — UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON
- Study coordinator: LEON-NOVELO, LUIS GONZALO
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.