Using green tea extract to prevent complications from cirrhosis
Epigallocatechin gallate for prevention of lethal cirrhosis complications
This study is looking at whether a compound from green tea called EGCG can help prevent liver cancer in people with cirrhosis, and it will track how this treatment affects certain markers in the liver to see if it’s safe and effective.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project ID | NIH-10922759 on NIH RePORTER |
What this research studies
This research investigates the potential of epigallocatechin gallate (EGCG), a compound found in green tea, to prevent the development of hepatocellular carcinoma (HCC) in patients with cirrhosis. The study aims to monitor changes in a specific liver secretome signature that indicates the risk of HCC, using a method that allows for precise tracking of treatment effects. By evaluating the safety and effectiveness of EGCG, the research seeks to provide a new preventive strategy for patients at high risk of liver cancer due to cirrhosis.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with cirrhosis who are at high risk for developing hepatocellular carcinoma.
Not a fit: Patients who do not have cirrhosis or those with established hepatocellular carcinoma may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could significantly reduce the risk of liver cancer in patients with cirrhosis, improving their survival rates.
How similar studies have performed: Previous studies have shown promising results with EGCG in preventing liver cancer in animal models, indicating potential for success in human trials.
Where this research is happening
Dallas, United States
- Ut Southwestern Medical Center — Dallas, United States (Active)
Researchers
- Principal investigator: Hoshida, Yujin — Ut Southwestern Medical Center
- Study coordinator: Hoshida, Yujin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.