Using green tea extract to prevent complications from cirrhosis
Official title: Epigallocatechin gallate for prevention of lethal cirrhosis complications
Funded at Ut Southwestern Medical Center · NIH-10922759 · Data updated 2026-11-12
This study is looking at whether a compound from green tea called EGCG can help prevent liver cancer in people with cirrhosis, and it will track how this treatment affects certain markers in the liver to see if it’s safe and effective.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project start | September 6, 2023 |
| Project end | August 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $585,642 |
| NIH project number | 5R01CA282178-02 |
| Project ID | NIH-10922759 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with cirrhosis who are at high risk for developing hepatocellular carcinoma.
✕Less likely to help
Patients who do not have cirrhosis or those with established hepatocellular carcinoma may not benefit from this research.
What this research studies
This research investigates the potential of epigallocatechin gallate (EGCG), a compound found in green tea, to prevent the development of hepatocellular carcinoma (HCC) in patients with cirrhosis. The study aims to monitor changes in a specific liver secretome signature that indicates the risk of HCC, using a method that allows for precise tracking of treatment effects. By evaluating the safety and effectiveness of EGCG, the research seeks to provide a new preventive strategy for patients at high risk of liver cancer due to cirrhosis.
Why it matters
Potential benefit: If successful, this research could significantly reduce the risk of liver cancer in patients with cirrhosis, improving their survival rates.
How similar studies have gone: Previous studies have shown promising results with EGCG in preventing liver cancer in animal models, indicating potential for success in human trials.
Where this research is happening
-
Ut Southwestern Medical Center
Dallas, United States Active
Researchers
- Principal investigator: Hoshida, Yujin — Ut Southwestern Medical Center
- Study coordinator: Hoshida, Yujin
Related research
Other NIH-funded projects on the same topics.
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Statin therapy for people with compensated cirrhosis
A big, long-term study at a major university is looking at whether statins can help people with compensated cirrhosis live longer and feel better.
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Liver Cirrhosis Network: Centers for Clinical Research
A multicenter study in people with cirrhosis from different causes (including HIV, NASH, and alcohol-related liver disease) to collect data and samples and test new ways to predict and monitor disease progression.
-
Outcomes in cirrhosis from different causes and the role of HIV and simvastatin
This study looks at how cirrhosis from alcohol, HIV, and other causes affects patients and whether simvastatin can influence outcomes.
-
Liver Cirrhosis Network: Mayo Clinic's Clinical Research Center
A Mayo Clinic-led project will follow and help people with compensated cirrhosis, using data, imaging, and a big AI tool to predict when complications may happen and test whether a statin can improve outcomes.
-
Understanding how risk factors affect progression of cirrhosis and response to statins in patients with cirrhosis
This project follows people with cirrhosis to see what factors speed up their liver disease and whether statin medicines help prevent worsening.
-
Cirrhosis Network study to understand mortality and therapies
A large, multi-center study in people with cirrhosis to find better ways to predict deaths and test the potential of statins to prevent complications like liver cancer and liver failure.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.