Using grape seed extract to improve communication between nerve and glial cells to help with chronic pain.
Official title: Grape Seed Extract Modulation of Peripheral and Central Nervous System Neuron-Glia Interactions
Funded at Missouri State University · NIH-10874826 · Data updated 2026-11-12
This study is looking at how grape seed extract might help improve communication between nerve cells in the brain and spinal cord to reduce chronic pain from conditions like jaw pain and migraines, so patients can learn about new natural ways to manage their pain.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Missouri State University NIH-funded |
| Lab location | 1 site (Springfield, United States) |
| Project start | April 1, 2024 |
| Project end | March 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $427,500 |
| NIH project number | 1R15AT012501-01A1 |
| Project ID | NIH-10874826 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from chronic pain conditions such as temporomandibular joint disorder (TMD) or migraines.
✕Less likely to help
Patients who do not experience chronic pain or have conditions unrelated to nerve-glial interactions may not benefit from this research.
What this research studies
This research investigates how grape seed extract (GSE), a natural supplement, can influence the communication between nerve cells and glial cells in the brain and spinal cord. The study focuses on understanding the mechanisms by which GSE may reduce chronic pain associated with conditions like temporomandibular joint disorder (TMD) and migraines. By examining the effects of GSE on specific receptors and signaling pathways, the research aims to identify how it can inhibit pain signaling and promote better pain management. Patients may benefit from insights into new dietary approaches for alleviating chronic pain.
Why it matters
Potential benefit: If successful, this research could provide a novel dietary intervention for managing chronic pain conditions.
How similar studies have gone: Previous research has shown promising results with grape seed extract in reducing pain signaling in preclinical models, indicating potential for success in this approach.
Where this research is happening
-
Missouri State University
Springfield, United States Active
Researchers
- Principal investigator: Durham, Paul L — Missouri State University
- Study coordinator: Durham, Paul L
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.