Using GPNMB to help heal bones
Official title: Delivery of GPNMB Therapeutics for Bone Regeneration
Funded at Northeast Ohio Medical University · NIH-11058411 · Data updated 2026-11-12
This study is exploring a new way to help bones heal using a special protein called GPNMB delivered through a gel, which could offer a safer and more effective option for people needing bone regeneration instead of traditional bone grafts.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northeast Ohio Medical University NIH-funded |
| Lab location | 1 site (Rootstown, United States) |
| Project start | March 18, 2024 |
| Project end | January 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $394,202 |
| NIH project number | 5R01AR083763-02 |
| Project ID | NIH-11058411 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals requiring bone regeneration, particularly those who may face complications from traditional grafting methods.
✕Less likely to help
Patients with conditions that do not require bone regeneration or those who have contraindications for the use of GPNMB therapeutics may not benefit from this research.
What this research studies
This research investigates a new treatment for bone regeneration using a protein called GPNMB, which has been shown to promote bone formation. The approach involves delivering GPNMB therapeutics through a specialized hydrogel that ensures the protein reaches the targeted area effectively. This method aims to overcome the limitations of traditional bone grafts, such as donor site complications and limited availability. Patients may benefit from a less invasive and more effective alternative for bone healing.
Why it matters
Potential benefit: If successful, this research could provide a safer and more effective method for bone regeneration, reducing the need for autologous bone grafts.
How similar studies have gone: Previous research has shown promise in using similar therapeutic agents for bone regeneration, indicating potential for success in this innovative approach.
Where this research is happening
-
Northeast Ohio Medical University
Rootstown, United States Active
Researchers
- Principal investigator: Oyewumi, Moses O — Northeast Ohio Medical University
- Study coordinator: Oyewumi, Moses O
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.