Using gold nanoparticles to enhance radiotherapy for triple negative breast cancer

Who could benefit from this research

What this research studies

This research investigates how gold nanoparticles can improve the effectiveness of radiotherapy for patients with triple negative breast cancer (TNBC). The approach focuses on overcoming the immunosuppressive effects of radiation therapy, which can hinder its benefits. By utilizing gold nanoparticles as radiosensitizers, the study aims to enhance the immune response against tumors and improve patient outcomes. The research will explore the combination of radiotherapy and immunotherapy to potentially increase the survival rates of TNBC patients.

Why it matters

Where this research is happening

• Henry Ford Health System
  Detroit, United States Active

Researchers

• Principal investigator: Janic, Branislava — Henry Ford Health System
• Study coordinator: Janic, Branislava

Related research

Other NIH-funded projects on the same topics.

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• Finding the best radiotherapy dose to use with immunotherapy for early-stage triple-negative breast cancer

  This study is looking for the best amount of radiation therapy to use alongside immunotherapy and chemotherapy for people with early-stage triple-negative breast cancer, to help improve their treatment results.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-11057010

• Best radiation dose with pre-surgery chemo and pembrolizumab for early-stage triple-negative breast cancer

  This project compares different radiation doses given before surgery together with chemotherapy and pembrolizumab for people with early-stage, node-positive triple-negative breast cancer to find the safest and most helpful approach.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-10880515

• Genomic study to understand how genetics and epigenetics shape triple-negative breast cancer in African ancestry

  This study looks at how inherited genes and gene activity affect triple-negative breast cancer in people of African ancestry to better understand why outcomes can be worse.

  NIH research Tuskegee University · Tuskegee Institute, United States · NIH-11621786

• Co-Targeting IL-6 and CDK4/6 to Prevent TNBC in Women Veterans

  A study aims to block two cancer-promoting pathways (IL-6 and CDK4/6) to prevent or reduce progression of triple-negative breast cancer in women veterans.

  NIH research Baltimore VA Medical Center · Baltimore, United States · NIH-11608792

• Linking heavy metal exposure to a tougher breast cancer type (TNBC)

  Aimed at understanding how heavy metals like cadmium might trigger a dangerous breast cancer type (TNBC) in people, especially those with BRCA1 risk, to identify possible future treatment strategies.

  NIH research University of Louisville · Louisville, United States · NIH-11567535

About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.