Using gliflozins to protect the heart during cardiac arrest
Official title: Attenuation of Reperfusion Injury by Gliflozins During Cardiac Arrest Leading to Improved Post-Resuscitation Myocardial Function and Survival
Funded at Edward Hines Jr VA Hospital · NIH-11098575 · Data updated 2026-11-12
This study is looking at whether a type of diabetes medication called gliflozins can help protect the heart from damage during cardiac arrest, and it's for anyone interested in improving heart health and survival after such emergencies.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Edward Hines Jr VA Hospital NIH-funded |
| Lab location | 1 site (Hines, United States) |
| Project start | January 1, 2022 |
| Project end | December 31, 2025 |
| Funding year | 2025 |
| NIH project number | 5I01BX005705-04 |
| Project ID | NIH-11098575 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who are at risk of cardiac arrest, particularly those with underlying heart conditions.
✕Less likely to help
Patients who are not at risk for cardiac arrest or those who do not have cardiovascular issues may not benefit from this research.
What this research studies
This research investigates how gliflozins, a class of drugs typically used for type 2 diabetes, can help reduce heart damage during cardiac arrest. When a person experiences cardiac arrest, blood flow to the heart and brain is interrupted, leading to severe tissue injury. The study aims to determine if administering gliflozins during cardiopulmonary resuscitation (CPR) can minimize this injury and improve heart function and survival rates after resuscitation. The research will involve experiments in animal models to assess the effectiveness of these drugs in protecting the heart during such critical situations.
Why it matters
Potential benefit: If successful, this research could lead to improved survival rates and better heart function for patients who experience cardiac arrest.
How similar studies have gone: Preliminary studies in animal models have shown promising results with similar approaches, indicating potential for success in this research.
Where this research is happening
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Edward Hines Jr VA Hospital
Hines, United States Active
Researchers
- Principal investigator: Gazmuri, Raul Jaime — Edward Hines Jr VA Hospital
- Study coordinator: Gazmuri, Raul Jaime
Related research
Other NIH-funded projects on the same topics.
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Multi-center study on how ventilation during CPR relates to cardiac arrest outcomes
A large, real-world study will look at how ventilation during CPR affects survival after out-of-hospital cardiac arrest in adults.
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Specialized post-arrest care after cardiac arrest
A large, nationwide effort tests whether transferring cardiac arrest patients to a specialized post-arrest care center improves recovery compared with usual care.
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Reduce bias in predicting brain recovery after cardiac arrest
This project aims to make brain-recovery predictions more accurate for people who survive cardiac arrest by comparing outcomes between the United States and Brazil.
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Fairer brain recovery predictions after cardiac arrest through U.S.–Brazil collaboration
This project aims to find better ways to predict brain recovery for people who survive cardiac arrest but have possible brain injury.
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Improving predictions of brain recovery after cardiac arrest
This project compares outcomes after cardiac arrest in the U.S. and Brazil to learn which tests best predict who will regain brain function for people who survive cardiac arrest.
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Reducing biased predictions of brain recovery after cardiac arrest
This project looks at cardiac arrest survivors in the US and Brazil to find more accurate ways to predict brain recovery and avoid premature stopping of life support.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.