Using gliflozins to protect the heart during cardiac arrest
Attenuation of Reperfusion Injury by Gliflozins During Cardiac Arrest Leading to Improved Post-Resuscitation Myocardial Function and Survival
This study is looking at whether a type of diabetes medication called gliflozins can help protect the heart from damage during cardiac arrest, and it's for anyone interested in improving heart health and survival after such emergencies.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Edward Hines Jr VA Hospital NIH-funded |
| Lab location | 1 site (Hines, United States) |
| Project ID | NIH-11098575 on NIH RePORTER |
What this research studies
This research investigates how gliflozins, a class of drugs typically used for type 2 diabetes, can help reduce heart damage during cardiac arrest. When a person experiences cardiac arrest, blood flow to the heart and brain is interrupted, leading to severe tissue injury. The study aims to determine if administering gliflozins during cardiopulmonary resuscitation (CPR) can minimize this injury and improve heart function and survival rates after resuscitation. The research will involve experiments in animal models to assess the effectiveness of these drugs in protecting the heart during such critical situations.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who are at risk of cardiac arrest, particularly those with underlying heart conditions.
Not a fit: Patients who are not at risk for cardiac arrest or those who do not have cardiovascular issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved survival rates and better heart function for patients who experience cardiac arrest.
How similar studies have performed: Preliminary studies in animal models have shown promising results with similar approaches, indicating potential for success in this research.
Where this research is happening
Hines, United States
- Edward Hines Jr VA Hospital — Hines, United States (Active)
Researchers
- Principal investigator: Gazmuri, Raul Jaime — Edward Hines Jr VA Hospital
- Study coordinator: Gazmuri, Raul Jaime
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.