Using genomic and spatial methods to control HIV-related tuberculosis outbreaks
Integrating genomic and spatial approaches for targeted control of HIV-associated tuberculosis epidemics
['FUNDING_R01'] · YALE UNIVERSITY · NIH-10676990
This study is looking to help people with tuberculosis (TB) who also have HIV by using new genetic tools to find out where TB spreads the most, so we can create better ways to find and treat TB in different communities in Southern Africa.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | YALE UNIVERSITY (nih funded) |
| Locations | 1 site (NEW HAVEN, UNITED STATES) |
| Trial ID | NIH-10676990 on ClinicalTrials.gov |
What this research studies
This research aims to improve tuberculosis (TB) control in areas with high rates of HIV by using advanced genomic techniques to identify and target specific TB transmission hotspots. By analyzing genetic data from TB bacteria and understanding community risk factors, the project seeks to implement more effective interventions tailored to the unique needs of different urban populations in Southern Africa. The approach focuses on enhancing the efficiency of TB case finding and treatment in settings where HIV is prevalent, ultimately aiming to reduce TB transmission and improve health outcomes for affected individuals.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults living with HIV in Southern Africa, particularly those in urban areas with high TB prevalence.
Not a fit: Patients who do not live in high HIV prevalence areas or who do not have HIV may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective TB control strategies that significantly reduce the incidence of TB among individuals living with HIV.
How similar studies have performed: Previous studies have shown that targeted interventions based on genomic data can improve disease control, suggesting that this approach has the potential for success.
Where this research is happening
NEW HAVEN, UNITED STATES
- YALE UNIVERSITY — NEW HAVEN, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: COHEN, THEODORE H — YALE UNIVERSITY
- Study coordinator: COHEN, THEODORE H
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.