Using genome information to understand mutations in proteins
Novel Use of Genome Information to Understand Mutations
['FUNDING_R01'] · IOWA STATE UNIVERSITY · NIH-10873985
This study is looking at how changes in our genes can affect the proteins they create, helping doctors understand if these changes are harmful or not, and how they might change how proteins work in the body.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | IOWA STATE UNIVERSITY (nih funded) |
| Locations | 1 site (AMES, UNITED STATES) |
| Trial ID | NIH-10873985 on ClinicalTrials.gov |
What this research studies
This research focuses on translating genome sequences into proteins to better understand how mutations affect their function. By leveraging advances in genome sequencing, the project aims to analyze large datasets to predict the characteristics of various protein mutants. Clinicians will gain insights into whether these mutations are harmful or benign, how they influence protein structure and dynamics, and their binding specificity. The study will utilize a combination of protein sequence data, structural information, and amino acid properties to characterize the impact of mutations on protein functionality.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with known genetic mutations that may affect protein function.
Not a fit: Patients without genetic mutations or those whose conditions are not related to protein functionality may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding of genetic mutations, aiding in the development of targeted therapies for various diseases.
How similar studies have performed: Other research has shown success in using genomic data to predict protein functionality, indicating that this approach has potential for meaningful advancements.
Where this research is happening
AMES, UNITED STATES
- IOWA STATE UNIVERSITY — AMES, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: JERNIGAN, ROBERT L — IOWA STATE UNIVERSITY
- Study coordinator: JERNIGAN, ROBERT L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.