Using genetics to improve atrial fibrillation care
Atrial Fibrillation Post-GWAS: Mechanisms to Treatment
['FUNDING_P01'] · CLEVELAND CLINIC LERNER COM-CWRU · NIH-11166567
This project uses genetic discoveries to develop better prevention and treatments for atrial fibrillation in adults.
Quick facts
| Phase | ['FUNDING_P01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CLEVELAND CLINIC LERNER COM-CWRU (nih funded) |
| Locations | 1 site (CLEVELAND, UNITED STATES) |
| Trial ID | NIH-11166567 on ClinicalTrials.gov |
What this research studies
You would be part of efforts that connect genetic risk signals for atrial fibrillation with real biological processes by analyzing human atrial tissue and genomic data alongside lab and computational models. Researchers will study how specific genes and interactions with metabolism, age, and obesity change heart cell behavior and contribute to AF. They will use patient tissue, advanced genomics, animal and cell models, and drug screens to move from genes to possible therapies. Some parts of the program involve patients undergoing procedures like ablation or donating clinical data or tissue to a biorepository.
Who could benefit from this research
Good fit: Ideal candidates are adults with atrial fibrillation, especially those undergoing ablation or willing to donate atrial tissue or clinical data for research.
Not a fit: People without atrial fibrillation, children, or those seeking immediate changes to their current care are unlikely to receive direct benefit from this research.
Why it matters
Potential benefit: If successful, this work could lead to personalized prevention strategies and new treatments that reduce AF episodes, progression, and stroke risk.
How similar studies have performed: Genome-wide studies have found many AF risk regions but have not yet produced approved new drugs, so this program applies newer experimental models and translational efforts that are promising but still largely unproven.
Where this research is happening
CLEVELAND, UNITED STATES
- CLEVELAND CLINIC LERNER COM-CWRU — CLEVELAND, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CHUNG, MINA KAY — CLEVELAND CLINIC LERNER COM-CWRU
- Study coordinator: CHUNG, MINA KAY
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.