Using genetically modified pig organs for liver transplants
Liver Xenotransplantation using CRISPR-modified Porcine Organs
This study is exploring how scientists can use CRISPR technology to change pig organs so they might be safe and suitable for liver transplants in people, which could help those in need of a transplant when human organs are hard to find.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-11031169 on NIH RePORTER |
What this research studies
This research investigates the use of CRISPR technology to modify pig organs for potential use in liver transplantation. It aims to overcome significant challenges such as the risk of infections and immune rejection that currently limit the use of animal organs in humans. By editing the pig genome, the researchers hope to create organs that are safer and more compatible for transplantation, ultimately addressing the shortage of human donor organs. Patients may benefit from this innovative approach if it leads to successful liver transplants using these modified organs.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with end-stage liver disease who are on the waiting list for a liver transplant.
Not a fit: Patients who are not candidates for liver transplantation or those with conditions that contraindicate surgery may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could significantly increase the availability of liver transplants for patients in need.
How similar studies have performed: Other research has shown promise in using genetically modified animal organs for transplantation, indicating a potential pathway for success in this area.
Where this research is happening
Philadelphia, United States
- University of Pennsylvania — Philadelphia, United States (Active)
Researchers
- Principal investigator: Markmann, James Francis — University of Pennsylvania
- Study coordinator: Markmann, James Francis
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.