Using genetic testing to improve treatment for hypertension and depression in diverse populations.
Official title: GeNYC: Genomic Implementation Research in the Diverse Settings and Populations of New York City
Funded at Icahn School of Medicine at Mount Sinai · NIH-11074366 · Data updated 2026-11-12
This study is looking at how genetic testing can help doctors choose the best treatments for conditions like high blood pressure, depression, and pain, especially for people in New York City, so that everyone can benefit from personalized care.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | September 14, 2024 |
| Project end | June 30, 2025 |
| Funding year | 2024 |
| Award (this year) | $184,191 |
| NIH project number | 3U01HG010248-05S3 |
| Project ID | NIH-11074366 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include adults of African ancestry who are dealing with hypertension, depression, or chronic pain.
✕Less likely to help
Patients who do not have hypertension, depression, or chronic pain may not benefit from this research.
What this research studies
This research investigates how genetic testing can guide treatment decisions for conditions like hypertension, depression, and pain in diverse populations, particularly in New York City. It involves two clinical trials that will assess the effectiveness of genotype-guided therapies, aiming to ensure that genomic medicine is accessible and relevant to various demographic groups. Patients will be monitored to evaluate how these personalized approaches impact their health outcomes over time.
Why it matters
Potential benefit: If successful, this research could lead to more effective and personalized treatment options for patients with hypertension and depression.
How similar studies have gone: Previous research has shown promising results in using genetic testing to tailor treatments for various conditions, indicating that this approach has potential for success.
Where this research is happening
-
Icahn School of Medicine at Mount Sinai
New York, United States Active
Researchers
- Principal investigator: Horowitz, Carol R — Icahn School of Medicine at Mount Sinai
- Study coordinator: Horowitz, Carol R
Related research
Other NIH-funded projects on the same topics.
-
Improving Breast Cancer Guideline Adherence in Nigeria
Aimed at helping doctors in Nigeria follow international guideline-based breast cancer care to improve outcomes for women with breast cancer.
-
Genetically Validated PCOS Subtypes for Better Diagnosis and Risk Stratification
Aimed at women with polycystic ovary syndrome (PCOS), this project uses genetic data and patient characteristics to define distinct PCOS subtypes and improve how we diagnose and estimate risk.
-
Closed-loop control of interneuron timing to influence seizures and memory in epilepsy
A study tests a brain-quieting system that uses light to precisely time certain brain cells in epilepsy-prone mice to see if this can lessen seizures and improve memory.
-
Understanding why some brain regions and cells accumulate tau in Alzheimer’s and related diseases
Researchers are studying why certain brain areas and neuron types accumulate tau protein in Alzheimer’s and related conditions, and how this leads to brain changes and symptoms.
-
Improving blood flow after stroke by breaking down NETs
Aims to see if breaking down neutrophil extracellular traps (NETs) after an ischemic stroke can improve blood flow and reduce brain injury in patients.
-
Aging and brain injury connection: learning how late-life TBI relates to Alzheimer’s and related dementias
This grant looks at whether traumatic brain injuries in people 65 and older are linked to Alzheimer’s disease and related dementias, using a large, harmonized set of long-term aging studies.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.