Using genetic information to improve treatment for brain injuries
Precision Medicine Approach: Using genomic information to guide TBI treatment
This study is looking at how changes in your genes after a mild to moderate brain injury can help doctors find better treatments just for you, like using thyroid hormone T4, to improve recovery and protect your brain.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-10832964 on NIH RePORTER |
What this research studies
This research investigates how genetic changes following mild to moderate traumatic brain injury (mTBI) can inform more effective treatments. By analyzing individual cells' genomic data, the study aims to identify specific gene alterations that contribute to the long-term effects of brain injuries. The researchers are particularly focused on how these genetic insights can lead to targeted therapies, such as the use of thyroid hormone T4, to enhance recovery and prevent further neurological damage. Patients may benefit from a more personalized approach to their treatment based on their unique genetic profiles.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals who have experienced mild to moderate traumatic brain injuries and are experiencing ongoing cognitive or neurological issues.
Not a fit: Patients with severe traumatic brain injuries or those who do not have identifiable genetic alterations related to their condition may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective, personalized treatments for patients suffering from the long-term effects of brain injuries.
How similar studies have performed: Other research has shown promise in using genomic approaches to tailor treatments for various conditions, suggesting that this method could also be effective for mTBI.
Where this research is happening
Los Angeles, United States
- University of California Los Angeles — Los Angeles, United States (Active)
Researchers
- Principal investigator: Gomez-Pinilla, Fernando — University of California Los Angeles
- Study coordinator: Gomez-Pinilla, Fernando
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.