Using genetic information to improve drug safety and effectiveness during surgery
Official title: Precision Pharmacogenomic Perioperative Prediction
Funded at Portland VA Medical Center · NIH-11252512 · Data updated 2026-11-12
This study is looking to improve surgery results by using information about how your genes affect how you respond to medications, helping doctors choose the best drugs for you and reduce the risk of side effects after surgery.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Portland VA Medical Center NIH-funded |
| Lab location | 1 site (Portland, United States) |
| Project start | February 1, 2023 |
| Project end | September 30, 2025 |
| Funding year | 2025 |
| NIH project number | 5I21HX003714-03 |
| Project ID | NIH-11252512 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include patients undergoing surgery who may be affected by variations in drug metabolism due to their genetic makeup.
✕Less likely to help
Patients who are not undergoing surgery or those without any genetic variations affecting drug response may not benefit from this research.
What this research studies
This research aims to enhance surgical outcomes by integrating pharmacogenomic data, which examines how a person's genes affect their response to medications, into the VA Surgical Quality Improvement Program (VASQIP). By collaborating with various VA databases and employing artificial intelligence, the project seeks to predict risks associated with postoperative drug reactions and optimize medication choices for patients. This approach could lead to more personalized and effective treatment plans during the perioperative period, ultimately improving patient safety and recovery.
Why it matters
Potential benefit: If successful, this research could significantly reduce adverse drug events and improve the effectiveness of medications used during and after surgery.
How similar studies have gone: Previous research has shown promising results in using pharmacogenomic data to tailor medication regimens, indicating that this approach has potential for success.
Where this research is happening
-
Portland VA Medical Center
Portland, United States Active
Researchers
- Principal investigator: Barrett, Thomas William — Portland VA Medical Center
- Study coordinator: Barrett, Thomas William
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.