Using genetic engineering to study Alzheimer's disease in marmosets
Genetic Engineering Core
This study is looking at how scientists can use gene editing to create marmosets that have features of Alzheimer's disease, which could help us learn more about the condition and find better treatments for people affected by it.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project ID | NIH-10899737 on NIH RePORTER |
What this research studies
This research focuses on genetically engineering common marmosets using CRISPR/Cas9 gene editing techniques to create models that mimic human Alzheimer's disease. The project aims to develop new technologies for germline gene editing and to produce fibroblast cell lines that can be differentiated into neuronal stem cells and neurons. By studying these genetically modified marmosets, researchers hope to gain insights into the mechanisms of Alzheimer's disease and improve our understanding of brain disorders. This work is crucial for advancing potential treatments and therapies for Alzheimer's.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would be individuals interested in advancements in Alzheimer's disease treatment and those with a familial history of the condition.
Not a fit: Patients with advanced Alzheimer's disease or those not genetically predisposed to the condition may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to breakthroughs in understanding and treating Alzheimer's disease.
How similar studies have performed: Other research using CRISPR technology in animal models has shown promise in understanding genetic diseases, indicating potential success for this approach.
Where this research is happening
Pittsburgh, United States
- University of Pittsburgh at Pittsburgh — Pittsburgh, United States (Active)
Researchers
- Principal investigator: Homanics, Gregg E. — University of Pittsburgh at Pittsburgh
- Study coordinator: Homanics, Gregg E.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.