Using genetic and protein tests to better diagnose and treat uveitis
Official title: Multi-omics Strategies to Improve Clinical Outcomes in Uveitis
Funded at University of California, San Francisco · NIH-11118834 · Data updated 2026-11-12
This project uses advanced microbial and host molecular testing to find causes of uveitis and guide treatment choices for people with eye inflammation.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | July 1, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $432,027 |
| NIH project number | 5R01EY036058-02 |
| Project ID | NIH-11118834 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are people with active uveitis who can provide a small eye-fluid sample (for example, aqueous humor) and clinical information for pathogen and gene-expression testing.
✕Less likely to help
People without uveitis or those with clearly non-infectious eye inflammation who are not sampled would not directly benefit from participating.
What this research studies
If you take part, you'll be asked to give a small eye-fluid sample and share clinical information so researchers can look for microbes and host responses. They will use metagenomic sequencing to find bacteria, viruses, or other organisms and examine antimicrobial resistance patterns. They will also measure gene activity and other biomarkers in your sample to find patterns that predict vision outcomes. Clinics around the world will share results so doctors can learn which pathogens and treatments work best in different places.
Why it matters
Potential benefit: If successful, this work could lead to faster, more accurate diagnoses of infectious uveitis and more targeted treatments that help preserve vision.
How similar studies have gone: Metagenomic sequencing and host transcript profiling have helped diagnose other infections and some eye diseases, but combining worldwide pathogen surveillance with host multi-omics in uveitis is a relatively new approach.
Where this research is happening
-
University of California, San Francisco
San Francisco, United States Active
Researchers
- Principal investigator: Doan, Thuy a — University of California, San Francisco
- Study coordinator: Doan, Thuy a
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.