Using gene regulation insights to improve treatment for COPD
Leveraging Variant-perturbed Gene Regulation to Support Precision Medicine in COPD
This study is looking at how tiny molecules called miRNAs affect gene behavior in people with Chronic Obstructive Pulmonary Disease (COPD), with the goal of finding personalized treatment options that could improve lung health based on individual genetic differences.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11038044 on NIH RePORTER |
What this research studies
This research investigates how micro-ribonucleic acids (miRNAs) influence gene regulation in Chronic Obstructive Pulmonary Disease (COPD). By examining the interactions between miRNAs and other biological molecules, the study aims to understand how genetic variants affect lung health and disease. The researchers will utilize advanced computational methods to model these interactions and identify potential therapeutic strategies tailored to individual patients. This approach seeks to enhance precision medicine for COPD by linking genetic information to effective treatments.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Chronic Obstructive Pulmonary Disease, particularly those with known genetic variants.
Not a fit: Patients without a diagnosis of COPD or those not carrying relevant genetic variants may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more personalized and effective treatment options for patients with COPD.
How similar studies have performed: Previous research has shown promise in using genetic insights and miRNA regulation to develop targeted therapies for lung diseases, indicating a potential for success in this approach.
Where this research is happening
Boston, United States
- Brigham and Women's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Glass, Kimberly Renee — Brigham and Women's Hospital
- Study coordinator: Glass, Kimberly Renee
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.