Using gene-drive systems to modify mosquito populations to combat malaria
Official title: Impact of gene-drive systems for population modification on malaria vector mosquitoes
Funded at University of California-Irvine · NIH-11086802 · Data updated 2026-11-12
This study is exploring new ways to help fight malaria by creating special mosquitoes that can resist the disease, making it easier to reduce its spread in areas where malaria is a big problem.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California-Irvine NIH-funded |
| Lab location | 1 site (Irvine, United States) |
| Project start | June 9, 2023 |
| Project end | May 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $1,030,493 |
| NIH project number | 5R01AI170692-03 |
| Project ID | NIH-11086802 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals living in malaria-endemic regions, particularly in sub-Saharan Africa.
✕Less likely to help
Patients who do not reside in malaria-affected areas or those who are not at risk of malaria infection may not benefit from this research.
What this research studies
This research investigates innovative genetic strategies to control malaria by modifying mosquito populations. It focuses on developing genetically-engineered strains of mosquitoes that can resist malaria parasites and reduce their transmission. The approach aims to create a sustainable solution that can adapt to the influx of wild mosquitoes and infected individuals in affected regions. By utilizing advanced gene-editing technologies, the project seeks to enhance the effectiveness of malaria control efforts in high-burden areas.
Why it matters
Potential benefit: If successful, this research could significantly reduce malaria transmission and improve health outcomes in affected populations.
How similar studies have gone: Other research has shown promise in using genetic approaches for vector control, indicating potential success for this novel strategy.
Where this research is happening
-
University of California-Irvine
Irvine, United States Active
Researchers
- Principal investigator: James, Anthony a. — University of California-Irvine
- Study coordinator: James, Anthony a.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.