Using fructose to enhance T cell function in cancer treatment
Leveraging fructose transport to create a privileged substrate to selectively fuel T cells
This study is looking at how fructose might help boost the energy and effectiveness of T cells, which are important for fighting cancer, so that we can develop better treatments for patients battling the disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sloan-Kettering Inst Can Research NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10977075 on NIH RePORTER |
What this research studies
This research investigates how fructose can be used as an alternative energy source to improve the function of T cells in fighting cancer. By understanding the metabolic limitations that T cells face in the hostile environment of solid tumors, the study aims to develop methods to enhance T cell activation and proliferation. The researchers will utilize advanced imaging techniques to monitor T cell metabolism in real-time, providing insights into how these cells can be better utilized in cancer therapies. The ultimate goal is to create more effective immunotherapies for patients with cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with solid tumors who are undergoing or considering immunotherapy treatments.
Not a fit: Patients with hematological cancers or those not receiving immunotherapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved immunotherapy treatments for cancer patients by enhancing T cell effectiveness.
How similar studies have performed: Other research has shown promise in using metabolic modulation to enhance T cell function, suggesting that this approach could be effective.
Where this research is happening
New York, United States
- Sloan-Kettering Inst Can Research — New York, United States (Active)
Researchers
- Principal investigator: Keshari, Kayvan R — Sloan-Kettering Inst Can Research
- Study coordinator: Keshari, Kayvan R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.