Using focused ultrasound to treat chronic tendon pain

Focused ultrasound-induced cavitation in elastic, anisotropic tissues: a treatment for tendinopathies

['FUNDING_R01'] · PENNSYLVANIA STATE UNIVERSITY, THE · NIH-11135500

This project is developing a new focused ultrasound treatment for people experiencing long-lasting tendon pain.

Quick facts

Phase['FUNDING_R01']
Study typeNih_funding
SexAll
SponsorPENNSYLVANIA STATE UNIVERSITY, THE (nih funded)
Locations1 site (UNIVERSITY PARK, UNITED STATES)
Trial IDNIH-11135500 on ClinicalTrials.gov

What this research studies

Many people suffer from chronic tendon pain, and current treatments don't always work well, showing mixed results. This project is creating a novel focused ultrasound therapy that aims to overcome the limitations of existing treatments for tendon injuries. The approach uses sound waves to precisely induce microdamage, like separating and fraying collagen fibers, which could help promote healing within the tendon. Researchers are also developing integrated imaging techniques to accurately guide and monitor the treatment in real-time. This work builds on early findings in animal models that showed promising results in preserving tendon strength compared to traditional therapies.

Who could benefit from this research

Good fit: Patients who experience chronic tendon pain lasting more than three months and have not found consistent relief from current treatments might be ideal candidates for future applications of this therapy.

Not a fit: Patients with acute tendon injuries or those whose pain is not related to the structural issues addressed by this specific ultrasound approach may not receive direct benefit from this particular treatment.

Why it matters

Potential benefit: If successful, this new focused ultrasound therapy could offer a more effective, consistent, and precisely controlled way to treat chronic tendon pain, potentially reducing discomfort and improving function for many patients.

How similar studies have performed: While existing therapies like dry needling and shock wave therapy have shown mixed results, this project is developing a novel focused ultrasound approach with integrated monitoring, building on initial promising results in animal models.

Where this research is happening

UNIVERSITY PARK, UNITED STATES

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.

View on NIH RePORTER →

Last reviewed 2026-05-15 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.