Using focused ultrasound to precisely target pain circuits in the brain
Official title: Translating an MR-guided focused ultrasound system for first-in-human precision neuromodulation of pain circuits
Funded at Vanderbilt University Medical Center · NIH-10805159 · Data updated 2026-11-12
This study is testing a new way to help manage pain using MRI and focused ultrasound, which could provide a safer and more precise treatment option for people dealing with pain, without relying on addictive medications.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University Medical Center NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project start | September 20, 2023 |
| Project end | August 31, 2026 |
| Funding year | 2023 |
| Award (this year) | $4,364,294 |
| NIH project number | 1UG3NS135551-01 |
| Project ID | NIH-10805159 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals experiencing chronic pain who have not found relief through conventional treatments.
✕Less likely to help
Patients with acute pain conditions or those who are not suitable candidates for neuromodulation therapies may not benefit from this research.
What this research studies
This research aims to develop a noninvasive system that uses magnetic resonance imaging (MRI) to guide focused ultrasound (FUS) for the precise modulation of brain regions involved in pain processing. By combining real-time imaging with targeted ultrasound stimulation, the approach seeks to improve the effectiveness of pain treatments while avoiding the risks associated with addictive medications. Patients will benefit from a more accurate and controlled method of pain management that is tailored to their specific needs. The research builds on previous successes in animal models and aims to translate these findings into human applications.
Why it matters
Potential benefit: If successful, this research could provide a new, non-addictive treatment option for patients suffering from chronic pain.
How similar studies have gone: Previous research has shown promising results in animal models using similar techniques, but this approach is novel in its application to human patients.
Where this research is happening
-
Vanderbilt University Medical Center
Nashville, United States Active
Researchers
- Principal investigator: Caskey, Charles F — Vanderbilt University Medical Center
- Study coordinator: Caskey, Charles F
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.