Using focused ultrasound and antibodies to improve treatment for cold melanoma tumors
Role of histotripsy synergized CD40 signaling in the re-engineering of cold tumors
This study is exploring a new way to help people with advanced melanoma that doesn't respond to current treatments by using focused ultrasound and an antibody to boost the immune system's ability to fight the cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project ID | NIH-11002232 on NIH RePORTER |
What this research studies
This research investigates a new approach to treat advanced-stage metastatic melanoma, particularly focusing on tumors that are resistant to current therapies. The study aims to combine focused ultrasound technology with an antibody treatment to enhance the immune response against 'cold' tumors, which typically do not respond well to existing immune therapies. By using a method that creates antigen depots in the tumor and activates immune cells, the researchers hope to improve the effectiveness of treatments and achieve better patient outcomes. The project will involve testing this innovative therapy in animal models before considering human applications.
Who could benefit from this research
Good fit: Ideal candidates for this research would be patients with advanced-stage metastatic melanoma, particularly those whose tumors are classified as cold and have not responded well to existing therapies.
Not a fit: Patients with early-stage melanoma or those whose tumors are highly immunogenic may not benefit from this specific research.
Why it matters
Potential benefit: If successful, this research could significantly improve treatment options and survival rates for patients with advanced melanoma, especially those with cold tumors.
How similar studies have performed: While the approach of combining ultrasound with immune therapies is innovative, similar strategies have shown promise in preliminary studies, suggesting potential for success.
Where this research is happening
Dallas, United States
- Ut Southwestern Medical Center — Dallas, United States (Active)
Researchers
- Principal investigator: Ranjan, Ashish — Ut Southwestern Medical Center
- Study coordinator: Ranjan, Ashish
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.