Using fly models to understand severe pediatric epilepsy
CRISPR Generated Genomic Templates to Evaluate Epileptogenesis
['FUNDING_OTHER'] · TEXAS A&M UNIVERSITY-KINGSVILLE · NIH-11093941
This study is looking at a serious type of epilepsy in kids by using fruit flies to mimic the condition, so researchers can better understand how it works and find new treatments to help those affected.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | TEXAS A&M UNIVERSITY-KINGSVILLE (nih funded) |
| Locations | 1 site (KINGSVILLE, UNITED STATES) |
| Trial ID | NIH-11093941 on ClinicalTrials.gov |
What this research studies
This research investigates Developmental and Epileptic Encephalopathy (DEE), a severe form of epilepsy in children, by creating fly models that mimic the disease. Researchers will use CRISPR technology to introduce specific mutations in these fly avatars, allowing them to study the underlying mechanisms of epilepsy and how different tissues respond to these mutations. The goal is to gain insights that could lead to the development of targeted therapies for patients suffering from this condition.
Who could benefit from this research
Good fit: Ideal candidates for this research are children diagnosed with Developmental and Epileptic Encephalopathy (DEE) or similar severe early-onset epileptic conditions.
Not a fit: Patients with epilepsy not related to Developmental and Epileptic Encephalopathy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new, tailored drug therapies for children with severe epilepsy.
How similar studies have performed: While the use of fly models in epilepsy research is established, the specific application of CRISPR-generated mosaics for DEE is a novel approach.
Where this research is happening
KINGSVILLE, UNITED STATES
- TEXAS A&M UNIVERSITY-KINGSVILLE — KINGSVILLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BOHM, RUDOLF — TEXAS A&M UNIVERSITY-KINGSVILLE
- Study coordinator: BOHM, RUDOLF
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.