Using fluoridated scaffolds to heal large bone injuries
Official title: Fluoridated scaffolds for the treatment of critical-size bone defects
Funded at VA Salt Lake City Healthcare System · NIH-11055315 · Data updated 2026-11-12
This study is testing a new type of bone graft made from special materials to help people heal from serious bone injuries when other treatments might not work well, and it aims to see how well these grafts support new bone growth over three months.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | VA Salt Lake City Healthcare System NIH-funded |
| Lab location | 1 site (Salt Lake City, United States) |
| Project start | March 1, 2023 |
| Project end | February 28, 2027 |
| Funding year | 2025 |
| NIH project number | 5I01RX003911-03 |
| Project ID | NIH-11055315 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with critical-size bone defects or those requiring orthopedic reconstruction due to trauma.
✕Less likely to help
Patients with minor bone injuries or those who do not require surgical intervention may not benefit from this research.
What this research studies
This research focuses on developing bioengineered bone grafts made from fluorapatite scaffolds to treat critical-size bone defects. These scaffolds aim to provide a solution for patients who require bone repair, particularly in cases where traditional methods like autografts and allografts are limited or pose risks. The approach involves creating scaffolds that can support the growth of new bone tissue, potentially leading to better healing outcomes. The research will assess the effectiveness of these scaffolds in promoting bone regeneration over a 12-week period.
Why it matters
Potential benefit: If successful, this research could provide a safer and more effective alternative for patients needing bone repair, reducing the risks associated with current grafting techniques.
How similar studies have gone: Previous research has shown promising results with bioengineered graft materials, indicating potential for success with this novel approach.
Where this research is happening
-
VA Salt Lake City Healthcare System
Salt Lake City, United States Active
Researchers
- Principal investigator: Agarwal, Jayant Prasad — VA Salt Lake City Healthcare System
- Study coordinator: Agarwal, Jayant Prasad
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.