Using FL2 siRNA to help spinal cord healing after injury
FL2 siRNA as a Novel Therapeutic Option to Induce Spinal Cord Regeneration Following Injury
This study is looking at how lowering a protein called Fidgetin-like 2 (FL2) can help nerves heal after a spinal cord injury, using a special delivery method to target the protein, with the hope of improving movement and bladder control for people with these injuries.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Henry M. Jackson Fdn for the Adv Mil/med NIH-funded |
| Lab location | 1 site (Bethesda, United States) |
| Project ID | NIH-10593477 on NIH RePORTER |
What this research studies
This research investigates the role of a protein called Fidgetin-like 2 (FL2) in spinal cord injuries and how reducing its levels can promote nerve regeneration. The study uses a technique involving small interfering RNA (siRNA) delivered in nanoparticles to target FL2 at the injury site. By silencing FL2, the researchers aim to enhance recovery of movement and bladder function in models of spinal cord injury. The research includes assessing the duration of FL2 silencing and evaluating both functional and molecular changes in the spinal cord.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults who have experienced spinal cord injuries and are seeking innovative therapeutic options.
Not a fit: Patients with spinal cord injuries that are not amenable to regenerative therapies or those with other complicating health conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that significantly improve recovery for individuals with spinal cord injuries.
How similar studies have performed: Previous studies have shown promising results in nerve regeneration using similar approaches, indicating potential for success in this novel application.
Where this research is happening
Bethesda, United States
- Henry M. Jackson Fdn for the Adv Mil/med — Bethesda, United States (Active)
Researchers
- Principal investigator: Byrnes, Kimberly — Henry M. Jackson Fdn for the Adv Mil/med
- Study coordinator: Byrnes, Kimberly
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.