Using fisetin to improve blood vessel health in older adults
Targeting cellular senescence with oral fisetin supplementation to improve vascular aging
This study is looking at how a natural compound called fisetin, found in some foods, might help improve blood vessel health in older mice by reducing aging cells, which could lead to new ways to treat heart problems as we get older.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado NIH-funded |
| Lab location | 1 site (Boulder, UNITED STATES) |
| Project ID | NIH-10886142 on NIH RePORTER |
What this research studies
This research investigates the effects of fisetin, a natural compound found in certain foods, on improving blood vessel function in older mice. The study aims to understand how reducing cellular senescence, which is the accumulation of aging cells, can benefit cardiovascular health. By using advanced techniques and mouse models, the research seeks to establish a connection between senescent cells and arterial dysfunction, potentially leading to new treatments for age-related cardiovascular diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults experiencing age-related cardiovascular issues or those interested in preventive health measures.
Not a fit: Patients who are not older adults or those without any cardiovascular concerns may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new dietary recommendations or supplements that improve vascular health and reduce the risk of cardiovascular diseases in older adults.
How similar studies have performed: Previous research has shown promise in targeting cellular senescence for improving health outcomes, suggesting that this approach may be effective.
Where this research is happening
Boulder, UNITED STATES
- University of Colorado — Boulder, United States (Active)
Researchers
- Principal investigator: Mahoney, Sophia Andrea — University of Colorado
- Study coordinator: Mahoney, Sophia Andrea
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.