Using Fingolimod and Ozanimod to treat cognitive issues caused by chemotherapy
Fingolimod and Ozanimod for the treatment and prevention of chemobrain
This study is looking at how chemotherapy can cause memory and thinking problems, often called chemobrain, and it’s testing whether certain medications can help improve brain health and cognitive function for patients experiencing these issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Saint Louis University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-10889081 on NIH RePORTER |
What this research studies
This research investigates the cognitive impairment known as chemobrain, which affects over half of patients undergoing chemotherapy. It focuses on understanding the underlying mechanisms, particularly mitochondrial dysfunction and neuroinflammation in the brain. The study aims to explore the therapeutic potential of S1P1 receptor antagonists, such as Fingolimod and Ozanimod, to alleviate these cognitive issues. Patients may be monitored for changes in cognitive function and brain health as part of the treatment process.
Who could benefit from this research
Good fit: Ideal candidates include cancer patients undergoing chemotherapy who are experiencing cognitive difficulties.
Not a fit: Patients who are not undergoing chemotherapy or do not experience cognitive impairment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to effective treatments for cognitive impairment in cancer patients, improving their quality of life.
How similar studies have performed: While the approach of targeting S1P receptors is promising, the specific application to chemobrain is relatively novel and has not been extensively tested in prior studies.
Where this research is happening
Saint Louis, United States
- Saint Louis University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Salvemini, Daniela — Saint Louis University
- Study coordinator: Salvemini, Daniela
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.