Using ferrets to better understand human diseases
National Ferret Research and Resource Institute (NFRRI) at University of Iowa
This study is creating specially modified ferrets to help scientists better understand human diseases that mice can't accurately show, so they can find new ways to treat conditions affecting the brain, pancreas, lungs, and even infections like COVID-19.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Alabama at Birmingham NIH-funded |
| Lab location | 1 site (Birmingham, United States) |
| Project ID | NIH-11233652 on NIH RePORTER |
What this research studies
This research focuses on developing genetically engineered ferrets as a model for studying human diseases that traditional mouse models cannot accurately represent. The University of Iowa is pioneering techniques to create ferrets with specific genetic alterations, allowing researchers to investigate diseases affecting the brain, pancreas, and lungs, as well as infectious diseases like SARS-CoV2. By utilizing these advanced models, the research aims to provide insights into disease mechanisms and potential therapies. The National Ferret Research and Resource Center supports this work by offering services to create new models and distribute biological materials to researchers across the country.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals with genetic or acquired diseases that are being modeled in ferrets.
Not a fit: Patients with conditions that are not being studied using ferret models may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for various human diseases by providing better models for understanding their biology.
How similar studies have performed: Other research has shown success in using alternative animal models for studying human diseases, indicating that this approach has potential.
Where this research is happening
Birmingham, United States
- University of Alabama at Birmingham — Birmingham, United States (Active)
Researchers
- Principal investigator: Engelhardt, John F — University of Alabama at Birmingham
- Study coordinator: Engelhardt, John F
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.